Now familiar to doctors, hyaluronan, formerly called hyaluronic acid or HA, is the biomacromolecule most directly responsible for joint health.* It is the major component of synovial fluid and is responsible for the structural integrity of articular cartilage.*

Hyaluronan is a vital, bioactive molecule found naturally in all the body's tissues and fluids.* It retains moisture in the skin, lubricates and maintains healthy connective tissues, and provides shock absorption and lubrication to the joints.* Long molecular chains of hyaluronan are also the primary constituents of vertebral disks, absorbing shock, and lubricating the core of the spine.* Bones consist of osseous tissue that makes up the skeletal system, supports the body, protects vital organs, and facilitates locomotion and mineral storage.* The formation and differentiation of cells including red and white blood cells are just some of hyaluronan's many roles in the body.*

Hyaluronan plays a vital role in bone's extracellular matrix. Hyaluronan influences the growth and differentiation of cells in the bone marrow, accelerating new bone formation.* Hyaluronan also aids the bone turnover process that is constantly occurring in the body.* Osteoblasts are active throughout the formation process, and are vital to the overall structural integrity of the bone by replacing cartilage with cancellous (spongy) bone during this important physiological process. Hyaluronan supplementation has a stimulatory effect on osteoblasts, encouraging cell growth and increasing bone mineralization, contributing to the overall healthy bone production process.*