To be compared to Baxyl^®, any oral hyaluronan supplement must be bioavailable (usable by the body), absorbed, AND effective. Firstly, hyaluronan must be completely hydrated in order to be bioavailable and absorbed. Secondly, once absorbed it must have the appropriate molecular characteristics, including molecular weight, to be effective.

Baxyl has been developed as a liquid because of the very nature of hyaluronan itself. Hyaluronan is among nature's most water-loving molecules. When dry and exposed to moisture, hyaluronan slowly absorbs up to 1000 times its weight in water, creating a thick, viscous fluid. If consumed dry as a tablet, the transit time from ingestion to excretion does not provide the necessary time for hydration of this incredibly hydrophilic molecule. Research indicates that little of the high molecular weight dry forms are absorbed before excretion. While some low molecular weight dry forms may be hydrated and absorbed during ingestion and digestion, they are not effective and may actually be detrimental to joint health.